Baylor College of Medicine · BiologyLonard Reproductive Lab
David M Lonard · Houston, Texas
Research Focus
David M Lonard's research lab focuses on understanding how sex hormones, particularly androgens and progesterone, influence reproductive biology at the molecular level. Using advanced techniques like cryo-electron microscopy, the lab investigates how hormone receptors interact with coregulators and DNA to regulate gene expression. Their work aims to reveal the structural mechanisms behind male and female reproductive processes, potentially addressing issues like infertility and reproductive disorders.
androgen receptorprogesterone receptorcryogenic electron microscopygene expressionreproductive biologycoregulatorsmolecular structurehormonal signalinginfertility
Research Aims
4AIM 01Determine the structure of the androgen receptor transcriptional complex using cryo-EM.
AIM 02Investigate the role of structural dynamics in progesterone receptor activation.
AIM 03Analyze the transcriptional functions of hormone receptor complexes in vitro.
AIM 04Phenotype engineered mouse models to study receptor function in reproductive health.
Skills the Lab Values
cryogenic electron microscopyprotein-protein interaction studiesmolecular cloningcell culturemouse modelsproteomicsin vitro transcription assaysstructural biology techniquesgenetic engineering
Output against the department
Publications139top 50% of dept.511th of 1,033
this lab
most publishedleast published
Citations7.9ktop 47% of dept.489th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.