Johns Hopkins University · Microbiology & ImmunologyBacterial Persistence Lab
Kim Davis · Baltimore, Maryland
Research Focus
Dr. Kim Davis's lab focuses on understanding how certain bacteria survive antibiotic treatment within the human body. These survival strategies can lead to relapsing infections, which are a growing public health concern. The lab uses a mouse model to study how bacteria interact with immune cells and how these interactions help them persist during antibiotic therapy. The ultimate goal is to find new ways to improve antibiotic treatments and combat these persistent infections.
antibiotic resistancebacterial persistenceimmune responsehost-pathogen interactionstherapeutic strategies
Research Aims
3AIM 01Identify the genetic changes in bacteria that survive antibiotic treatment.
AIM 02Determine bacterial targets critical for antibiotic persistence in the host.
AIM 03Assess how immune cell interactions promote bacterial survival during antibiotic therapy.
Skills the Lab Values
cell culturemouse modelsflow cytometrygene expression analysisproteomicsmass spectrometrybiological assaysRNA analysisdata modeling