University of Alabama at Birmingham · GeneticsMarsiglia Signaling Lab
William M Marsiglia · Birmingham, Alabama
Research Focus
Dr. William M Marsiglia's lab focuses on understanding how a key protein called AKT becomes activated and interacts with other proteins in both healthy and diseased cells. They use advanced imaging techniques to visualize these processes in real time, which can provide insights into diseases and help identify new treatment targets. The research aims to enhance our understanding of cellular functions related to growth and metabolism and how they are impacted by various diseases.
AKTcell signalingdisease mechanismsbioluminescenceprotein interactionsconformational dynamicscell proliferationpathological conditionsbiophysical assays
Research Aims
5AIM 01Investigate the conformational changes of AKT during activation.
AIM 02Explore how AKT associates with cell membranes in different environments.
AIM 03Examine the interactions between AKT and its protein partners.
AIM 04Identify how these mechanisms differ under pathological conditions.
AIM 05Develop assays to measure protein complex formation in live cells.
Skills the Lab Values
bioluminescence assaysproximity labelingprotein purificationcell culture techniqueslive cell imagingcell signaling analysisWestern blottingkinetic measurement techniquesdata analysis with Python
Output against the department
Publications27bottom 3% of dept.249th of 259
this lab
most publishedleast published
Citations570bottom 2% of dept.254th of 259
this lab
most citedleast cited
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