University of Pennsylvania · PhysiologyGrishchuk Mechanics Lab
Ekaterina L Grishchuk · Philadelphia, Pennsylvania
Research Focus
Dr. Ekaterina L. Grishchuk’s research lab at the University of Pennsylvania focuses on understanding how molecular machines, particularly kinetochores, operate during cell division. The lab studies the mechanics of how chromosomes are segregated, which is crucial for maintaining genetic stability in cells. Through innovative laboratory techniques, they investigate the forces involved in these processes at a molecular level, providing insights that could impact our understanding of various health issues, including cancer and other genomic disorders.
biomechanicschromosome segregationkinetochorescell divisiongenomic instabilitymicrotubulesforce sensitivitymolecular machinesphosphorylationneural plasticity
Research Aims
5AIM 01Determine how kinetochores travel with microtubule ends during cell division.
AIM 02Investigate the friction and force sensitivity of microtubule-binding proteins.
AIM 03Analyze how mechanical tension influences phosphorylation patterns in kinetochores.
AIM 04Develop innovative assays to study molecular interactions and forces.
AIM 05Elucidate the mechanisms of chromosome stability to address aneuploidy issues.
Skills the Lab Values
single-molecule force spectroscopyin vitro assaysprotein purificationmicroscopy techniquesadvanced theoretical modelingcell culturekinetochore complex assemblymolecular mechanicsbiophysical analysischemical gradient reconstruction
Output against the department
Publications92bottom 24% of dept.216th of 286
this lab
most publishedleast published
Citations4.0kbottom 34% of dept.189th of 286
this lab
most citedleast cited
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