University of Chicago · BiochemistryPan SnoRNA Lab
Tao Pan · Chicago, Illinois
Research Focus
Dr. Tao Pan's lab at the University of Chicago focuses on understanding small nucleolar RNAs (snoRNAs), which are important molecules that help guide modifications in ribosomal RNA and can influence gene expression. By using advanced sequencing technologies, the lab aims to uncover the roles and interactions of these snoRNAs in human cells and how they impact various biological processes and diseases. This work could provide new insights into genome regulation and RNA-based therapies.
snoRNARNA-RNA interactionsgene expression regulationsequencing technologyRNA modifications
Research Aims
5AIM 01Identify the cellular RNA targets of the snoRNAome using advanced RNA-RNA interaction sequencing methods.
AIM 02Investigate the impact of snoRNA-mRNA interactions on gene expression across the transcriptome.
AIM 03Develop new techniques to characterize snoRNA-RNA interactions and understand their biological significance.
AIM 04Map 2O-methyl and pseudouridine modifications in mRNAs to understand their regulation by snoRNAs.
AIM 05Explore the functional consequences of specific snoRNA deletions on RNA and protein expression.
Skills the Lab Values
RNA sequencingcell culturemRNA stability assayskethoxal-assisted RNA-RNA interaction sequencing (KARR-seq)gene knockout techniquesbioinformatics for transcriptomicsPCRdata analysis using software for sequencing data
Output against the department
Publications240top 31% of dept.125th of 402
this lab
most publishedleast published
Citations32ktop 10% of dept.42nd of 402
this lab
most citedleast cited
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