Stony Brook University · Microbiology & ImmunologyFungal Pathogenesis and Immunity Lab
Maurizio Del Poeta · Stony Brook, New York
Research Focus
Dr. Maurizio Del Poeta's lab at Stony Brook University explores the biology of harmful fungi, particularly how they infect immunocompromised patients, such as those with HIV. The research focuses on understanding the immune response to fungal infections and developing novel antifungal treatments that target specific enzymes unique to fungi, which can help improve patient outcomes. By utilizing mouse models and high-throughput screening, the lab aims to provide new insights and therapeutic strategies against invasive fungal infections.
Cryptococcus neoformanssphingosine kinaseantifungal developmentfungal pathogenesisimmune response
Research Aims
5AIM 01Investigate the immune mechanisms regulating cryptococcal granuloma formation.
AIM 02Identify how sphingosine kinase influences the reactivation of cryptococcosis.
AIM 03Develop novel antifungal agents targeting sterylglucosidases.
AIM 04Optimize lead compounds through medicinal chemistry techniques.
AIM 05Assess the efficacy and safety of new antifungal inhibitors in vivo.
Skills the Lab Values
mouse modelscell culturehigh through-put screeningbiochemical assaysstructure-based drug design
Output against the department
Publications203top 31% of dept.152nd of 486
this lab
most publishedleast published
Citations8.2ktop 44% of dept.212th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.