University of Vermont · PhysiologyTrybus Myosin Lab
Kathleen M Trybus · Burlington, Vermont
Research Focus
Dr. Kathleen M Trybus and her lab at the University of Vermont focus on understanding the biology of malaria-causing parasites known as Plasmodium. By studying specific proteins called myosins that help these parasites move and invade host cells, they aim to identify new targets for drug development. This research is crucial for combatting malaria, especially given the recent challenges with vaccine efficacy and drug resistance.
malariaPlasmodiummyosingliding motilitydrug targetscell biologyprotein structuredrug resistance
Research Aims
3AIM 01Define the roles of myosin proteins PfMyoA and PfMyoB in the malaria lifecycle.
AIM 02Determine how small molecule inhibitors affect PfMyoA's activity.
AIM 03Investigate the roles of less-studied myosins PfMyoF and PfMyoK in Plasmodium biology.
Skills the Lab Values
X-ray crystallographycryo-EMlive cell imaginggenetic investigationmotility assaysoptical trap assaysPCRcell culturephase-contrast microscopyin vitro assays
Output against the department
Publications257top 21% of dept.61st of 286
this lab
most publishedleast published
Citations10ktop 31% of dept.89th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.