NKUNorthern Kentucky University · Chemistry
Guy Translation Lab
Michael P. Guy · Highland Heights, Kentucky
Research Focus
Michael P. Guy's lab at Northern Kentucky University focuses on how modifications to transfer RNA (tRNA) affect the translation process in various eukaryotic organisms. Through their research, they investigate the molecular mechanisms behind these modifications and their implications for human health, particularly in relation to diseases like intellectual disability and diabetes. Students in the lab gain hands-on experience in modern biomedical research techniques while contributing to important discoveries in cellular biology.
tRNA modificationstranslationbiomedical researchyeast modelsdisease mechanisms
Research Aims
5AIM 01Examine the roles of Trm732 and Trm734 in tRNA modification using various biochemical techniques.
AIM 02Identify which tRNAs are affected by the loss of anticodon loop modifications.
AIM 03Verify a guide RNA's role in forming a human tRNA modification.
AIM 04Determine modifications in the body of the tRNA important for translation and stability.
AIM 05Investigate biochemical and genetic aspects of tRNA stability in different yeast species.
Skills the Lab Values
molecular modelingnext generation sequencingbiochemical techniquesgeneticsreporter assaysbioinformaticsPCRcell culturedata analysis
Output against the department
Publications26bottom 5% of dept.206th of 216
this lab
most publishedleast published
Citations947bottom 6% of dept.202nd of 216
this lab
most citedleast cited
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