Case Western Reserve University · GeneticsLaboratory of Cellular Stress Responses
Maria Hatzoglou · Cleveland, Ohio
Research Focus
Dr. Maria Hatzoglou's lab focuses on how cells adapt to stress, specifically dehydration, by regulating protein synthesis. This research is important for understanding and treating diseases like diabetes and dry eye syndrome, which are linked to problems with cellular responses to stress. By studying how cells adjust their internal processes during dehydration, the lab aims to uncover new therapeutic strategies to improve cell survival in various health conditions.
osmoadaptationprotein synthesisdiabetesdry eye syndromecellular stressmolecular mechanismsRNA binding proteinstranslational regulationamino acid transport
Research Aims
3AIM 01Characterize the translation landscape during osmoadaptation.
AIM 02Investigate the interplay between translation regulation and liquid-liquid phase separation of RNA binding proteins.
AIM 03Determine RNA binding patterns and LLPS for specific RBPs during osmoadaptation.
Skills the Lab Values
cell cultureRNA sequencingWestern blotmolecular biology techniquesliquid-liquid phase separationnutrient transport assaystranscriptome analysisprotein binding assaysgenetic transcription
Output against the department
Publications170top 47% of dept.120th of 259
this lab
most publishedleast published
Citations11ktop 46% of dept.120th of 259
this lab
most citedleast cited
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