EUEmory University · Genetics
Transposable Elements and Neurodegeneration Lab
Peng Jin · Atlanta, Georgia
Research Focus
Dr. Peng Jin's lab focuses on understanding how certain elements of our DNA, particularly transposable elements (TEs) and dynamic DNA modifications, influence brain health and diseases like Alzheimer's. They investigate how a protein called TDP-43 affects these DNA elements and contributes to neurodegeneration, aiming to uncover new targets for potential treatments. The research combines genetics and epigenetics to shed light on complex brain processes and their implications for neurological disorders.
Alzheimer's Diseasetransposable elementsdynamic DNA modificationsepigeneticsTDP-43neurodegenerationRNA regulation3D organoidsgene expressionbrain development
Research Aims
5AIM 01Investigate the role of TDP-43 in regulating transposable elements in Alzheimer's disease.
AIM 02Elucidate how dynamic DNA modifications influence brain function and neurodevelopment.
AIM 03Identify transposable elements that contribute to neurodegenerative processes in the brain.
AIM 04Explore the potential of TDP-43 as a molecular target for new Alzheimer's therapies.
AIM 05Understand the interplay between DNA and RNA in gene regulation during aging and disease.
Skills the Lab Values
DNA sequencingRNA extraction and analysiscell culture3D organoid modelingepigenetic profilingCRISPR gene editingbioinformaticsimmunohistochemistryquantitative PCRmethylation analysis
Output against the department
Publications365top 22% of dept.56th of 259
this lab
most publishedleast published
Citations29ktop 20% of dept.51st of 259
this lab
most citedleast cited
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