University of Rochester · BiologyThe Senescence Solutions Lab
Hengwei Zhang · Rochester, New York
Research Focus
Dr. Hengwei Zhang's research lab focuses on understanding how cellular aging affects bone healing, especially in elderly patients who suffer from fractures. His work investigates a specific type of aging-related cell known as detrimental senescent cells that hinder the healing process. By exploring the mechanisms behind these cells, the lab aims to develop novel therapies to improve recovery from bone fractures in older adults.
cell senescenceagingbone fracturesfracture healingsenolytic drugs
Research Aims
5AIM 01Investigate the role of detrimental senescent cells in aging fracture repair.
AIM 02Characterize the phenotypic features of detrimental senescent cells.
AIM 03Explore the molecular mechanisms affecting mesenchymal progenitor cells during fracture healing.
AIM 04Identify new therapeutic targets in the treatment of geriatric fractures.
AIM 05Evaluate the effects of specific cell removal on fracture healing outcomes.
Skills the Lab Values
cell culturesingle cell RNA sequencinganimal modelsflow cytometryPCR
Output against the department
Publications116bottom 41% of dept.607th of 1,033
this lab
most publishedleast published
Citations2.6kbottom 19% of dept.833rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.