UWMUniversity of Wisconsin-Madison · Biology
Talaat Immunology Lab
Adel M Talaat · Madison, Wisconsin
Research Focus
Dr. Adel M. Talaat's research lab at the University of Wisconsin-Madison focuses on understanding tuberculosis and its interactions with other infections, particularly COVID-19. The lab aims to improve the efficacy of tuberculosis vaccines using innovative mRNA technology and nanoparticle delivery systems. By studying these interactions in mouse models, the research could lead to better control strategies for both diseases, significantly impacting public health.
TuberculosisSARS-CoV-2mRNA VaccinesImmunopathogenesisNano-adjuvantVaccine DevelopmentSuperinfectionImmune Response
Research Aims
5AIM 01Assess the impact of SARS-CoV-2 superinfection on tuberculosis progression in mice.
AIM 02Develop and evaluate mRNA vaccines against tuberculosis using novel delivery systems.
AIM 03Characterize the immunological responses during concurrent infections of TB and COVID-19.
AIM 04Investigate the role of specific cytokines in TB immunopathogenesis during superinfection.
AIM 05Explore the safety and efficacy of new TB vaccines in animal models, including guinea pigs.
Skills the Lab Values
mRNA vaccine designNanoparticle technologyMouse modelsImmunology techniquesCytokine profilingPathogen challenge assaysHistopathologyData analysis using R or Python
Output against the department
Publications93bottom 31% of dept.704th of 1,033
this lab
most publishedleast published
Citations4.0kbottom 30% of dept.719th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.