University of California-San Francisco · Microbiology & ImmunologyThe Antibody Evolution Lab
Angela Marie Phillips · San Francisco, California
Research Focus
Dr. Angela Marie Phillips' lab at UCSF focuses on how antibodies evolve and adapt to combat the SARS-CoV-2 virus. The research explores the physical properties of antibodies and how these influence their effectiveness in attaching to diverse viral variants. By understanding these mechanisms, the lab aims to pave the way for designing better antibodies that can protect against current and future viruses.
SARS-CoV-2antibody affinity maturationB-cell dynamicsbiophysical propertiesbroadly neutralizing antibodies
Research Aims
3AIM 01Quantitate the biophysical effects of mutations in anti-SARS-CoV-2 spike antibodies.
AIM 02Evaluate the contributions of antibody biophysical properties to B-cell fitness from human samples.
AIM 03Define the impact of selection pressure during antibody affinity maturation.
Skills the Lab Values
high-throughput cell-display techniquesantibody engineeringmolecular evolution methodsB-cell proliferation analysisbioinformatics modeling
Output against the department
Publications1bottom 1% of dept.481st of 486
this lab
most publishedleast published
Citations0bottom 1% of dept.480th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.