Virginia Commonwealth University · EngineeringAeroLung Innovations
P. Worth Longest · Richmond, Virginia
Research Focus
Dr. P. Worth Longest's research focuses on developing a new method for treating patients with acute lung injuries and respiratory distress. Instead of using traditional liquid treatments that require invasive procedures, the lab is working on a dry powder aerosol lung surfactant that can be inhaled easily and efficiently. This innovative approach aims to provide faster and more effective treatment for patients before they critically need mechanical ventilation.
lung surfactantaerosol deliveryacute respiratory distress syndromehypoxemiasynthetic surfactantsventilation supportdry powder inhaleranimal modelsformulation development
Research Aims
3AIM 01Develop a synthetic surfactant dry powder aerosol formulation for rapid aerosolization.
AIM 02Optimize delivery strategies and devices for safe aerosol administration in different ventilation modes.
AIM 03Test the efficacy of synthetic surfactant formulations in animal models of acute lung injury.
Skills the Lab Values
aerosolization techniquesformulation chemistryin vitro experimentsanimal handling (rats)computational fluid dynamics (CFD) modelingdevice developmenthigh flow nasal cannula therapyin vivo efficacy testingsynthetic surfactant formulation
Output against the department
Publications188bottom 49% of dept.141st of 278
this lab
most publishedleast published
Citations8.1ktop 46% of dept.128th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.