University of California-Berkeley · BiochemistryTuberculosis Immunology Research Lab
Sarah A Stanley · Berkeley, California
Research Focus
Dr. Sarah A. Stanley's lab focuses on understanding how the bacteria Mycobacterium tuberculosis (Mtb) suppresses the human immune system, which allows for chronic infections. The lab investigates two key components, the ESX-1 secretion system and a lipid called PDIM, to see how they work together to evade the immune response. By studying these mechanisms in mouse models, the lab aims to uncover new potential therapies to combat tuberculosis, one of the deadliest infectious diseases.
Mycobacterium tuberculosisimmune suppressionESX-1lipid virulence factorschronic infectionT cell responsetype I interferonsth17 cellspathogen immunity
Research Aims
3AIM 01Investigate whether ESX-1 and PDIM operate within the same virulence pathway.
AIM 02Test the role of IL-23 suppression in Th17 differentiation.
AIM 03Evaluate if type I interferon induction is necessary for the virulence of ESX-1 and PDIM mutants.
Skills the Lab Values
Mouse modelsFlow cytometryProteomicsIn vivo experimentationGenetic epistasis analysisCell cultureBiological assaysCytokine profilingImmunological assays
Output against the department
Publications128bottom 36% of dept.254th of 402
this lab
most publishedleast published
Citations7.9kbottom 43% of dept.231st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.