Yale University · BiochemistryKoleske Neurodevelopment Lab
Anthony J Koleske · New Haven, Connecticut
Research Focus
Dr. Anthony Koleske's lab at Yale University focuses on understanding the role of the TRIO gene in neurodevelopmental disorders like autism and schizophrenia. The lab investigates how specific genetic variants affect TRIO protein function and aims to identify small molecules to modulate its activity as potential therapeutic strategies. Through biochemical assays and advanced cell models, the lab seeks to elucidate the underlying mechanisms of neuronal development influenced by TRIO.
TRIO geneneurodevelopmental disordersschizophreniaautismguanosine nucleotide exchange factorsneuronal developmentsmall molecule modulatorssignaling pathwayscellular morphology
Research Aims
3AIM 01Identify small molecules that positively or negatively modulate TRIO GEF1 activity.
AIM 02Evaluate the efficacy of identified small molecules in cellular assays.
AIM 03Explore how TRIO GEF1 activity affects neuronal development and synaptic transmission.
Skills the Lab Values
PCRcell culturehigh throughput screeningCRISPRprotein purificationbiochemistry assayselectrophoresisfluorescence microscopyquantitative proteomicsdata analysis with Python
Output against the department
Publications196top 43% of dept.171st of 402
this lab
most publishedleast published
Citations12ktop 43% of dept.172nd of 402
this lab
most citedleast cited
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