University of Florida · PharmacologyNuclear Receptor Immunology Lab
Laura A Solt · Gainesville, Florida
Research Focus
Dr. Laura Solt's lab at the University of Florida focuses on understanding how certain proteins, known as nuclear receptors, influence the development and behavior of immune cells called TH17 cells, which are important in chronic inflammation and autoimmune diseases. By studying the role of these receptors and their interaction with small molecules, the lab aims to uncover new therapeutic strategies for treating conditions like colitis and Crohn's disease.
TH17 cellsnuclear receptorschronic inflammationautoimmune diseasesligand regulationRORREV-ERBtranscription regulationpharmacological approaches
Research Aims
5AIM 01Explore how ROR regulates TH17 cell development
AIM 02Investigate the role of ligands in ROR activity
AIM 03Define heme as a signaling molecule for REV-ERBa
AIM 04Determine the impact of REV-ERBa on TH17-mediated inflammation
AIM 05Identify potential therapeutic strategies targeting nuclear receptors.
Skills the Lab Values
cell culturemouse modelsRT-PCRWestern blotflow cytometryin vivo studiesRNA sequencingdata analysisbioinformatics
Output against the department
Publications115bottom 32% of dept.313th of 462
this lab
most publishedleast published
Citations6.7kbottom 47% of dept.244th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.