University of Rochester · BiochemistryThe RNA Decay Lab
Lynne E Maquat · Rochester, New York
Research Focus
Dr. Lynne Maquat's lab at the University of Rochester explores how cells manage their RNA molecules, particularly focusing on a process called nonsense-mediated mRNA decay (NMD). This process helps eliminate faulty RNA that could result from genetic errors and is crucial for maintaining healthy gene expression. The lab's research aims to understand how disruptions in these RNA processes could relate to diseases like fragile X syndrome and various muscle disorders.
RNA metabolismnonsense-mediated mRNA decayfragile X syndromeimmune responsemRNA translationgene expressionRNA-binding proteinsmuscle disordersCOVID-19 research
Research Aims
5AIM 01Investigate the molecular mechanisms of nonsense-mediated mRNA decay.
AIM 02Examine how NMD factors contribute to cellular health and disease.
AIM 03Understand the role of RNA-binding proteins in immune responses.
AIM 04Explore the interactions between mRNA and cap-binding proteins in gene expression.
AIM 05Study the implications of RNA metabolism in neuromuscular disorders.
Skills the Lab Values
PCRRNA sequencingcell culturemolecular cloningWestern blotmouse modelsimmunohistochemistrybiochemical assaysdata interpretation
Output against the department
Publications266top 26% of dept.103rd of 402
this lab
most publishedleast published
Citations24ktop 16% of dept.65th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.