Stanford University · BiologyThe Apoptosis Initiative
Gerald R. Crabtree · Stanford, California
Research Focus
Dr. Gerald R. Crabtree's lab focuses on developing innovative small molecules to treat blood cancers, specifically Diffuse Large B Cell Lymphoma (DLBCL). They employ a unique strategy to trick cancer cells into activating their own cell death mechanisms using engineered compounds that target specific genes involved in cancer growth. This research could lead to more precise and effective cancer therapies with fewer side effects.
cancer therapyproapoptotic genesbifunctional moleculesDiffuse Large B Cell Lymphomatranscriptional activation
Research Aims
5AIM 01Develop small molecules that induce cancer cell apoptosis
AIM 02Investigate mechanisms of action for novel therapeutics
AIM 03Test compound efficacy in patient-derived xenograft models
AIM 04Optimize drug properties for stability and solubility
AIM 05Conduct multidisciplinary research including chemistry and cancer biology.
Skills the Lab Values
Chemically Induced Proximitymolecular designcell cultureanimal modelschemotherapy techniques
Output against the department
Publications210top 31% of dept.319th of 1,033
this lab
most publishedleast published
Citations31ktop 10% of dept.106th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.