University of Colorado Boulder · BiochemistryThe Myosin Dynamics Lab
Leslie Anne Leinwand · Boulder, Colorado
Research Focus
Dr. Leslie Anne Leinwand's lab focuses on understanding how muscle cells adapt and change in response to various stimuli such as exercise and genetic mutations. They study myosin, a key protein in muscle function, to explore how it is replaced and repaired over time, particularly in relation to heart and skeletal muscles. The lab uses advanced imaging techniques to measure protein turnover and investigate how these processes are influenced by factors like biological sex and disease-causing mutations.
myosinsmuscle physiologysarcomere dynamicsprotein turnovercardiomyopathiesgenetic mutationsubiquitinationmuscle adaptationbiological sexexercise response
Research Aims
5AIM 01Investigate the rates of protein turnover in different muscle types.
AIM 02Explore how biological sex and activity influence sarcomere dynamics.
AIM 03Assess the impact of ubiquitination on myosin and muscle function.
AIM 04Determine how mutations in myosin genes lead to cardiomyopathy and myopathy.
AIM 05Develop novel therapeutic approaches based on myosin biology.
Skills the Lab Values
multi-isotope imaging mass spectrometry (MIMS)electron microscopy (EM)single myosin molecule live cell imagingstable isotope labelingubiquitin proteomicscell culturegenetic mutagenesisdynamic imagingdata analysisanimal models
Output against the department
Publications485top 9% of dept.35th of 402
this lab
most publishedleast published
Citations32ktop 10% of dept.40th of 402
this lab
most citedleast cited
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