University of Virginia-Main Campus · NeuroscienceHair Cell Mechanobiology Lab
Jung-Bum Shin · Charlottesville, Virginia
Research Focus
Professor Jung-Bum Shin's lab studies how specialized proteins in hair cells help us hear. They focus on a protein called Myosin 7a (MYO7A), which is crucial for detecting sounds. The lab explores the different versions of this protein and how they affect hearing, especially looking into ways they can be repaired and regulated. Their findings aim to improve gene therapy approaches for hearing loss caused by MYO7A mutations.
hair cellsMyosin 7acochlear mechanicstip-link repairgene therapytranscriptional regulationhearing lossisoformsmolecular mechanisms
Research Aims
3AIM 01Investigate the role of MYO7A in tip-link tension and frequency tuning.
AIM 02Explore the mechanisms of tip-link repair mediated by MYO7A.
AIM 03Examine the transcriptional regulation of MYO7A and its enhancer elements.
Skills the Lab Values
electrophysiologyoptical coherence tomographyelectron microscopyimmunofluorescenceChIP-Seqmouse modelsgenetic modificationbiochemical assaystissue culture
Output against the department
Publications41bottom 7% of dept.618th of 671
this lab
most publishedleast published
Citations853bottom 4% of dept.646th of 671
this lab
most citedleast cited
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