University of Minnesota-Twin Cities · NeuroscienceEpilepsy Mechanisms Research Unit
Esther Krook-Magnuson · Minneapolis, Minnesota
Research Focus
Dr. Esther Krook-Magnuson's lab at the University of Minnesota focuses on understanding the brain's mechanisms involved in epilepsy, particularly how the cerebellum influences seizure activity. The lab is investigating the connections between the hippocampus and the supramammillary area, aiming to reveal how these brain regions interact and affect neurological functions. Their research has the potential to lead to new treatment strategies for temporal lobe epilepsy and other neurological disorders.
temporal lobe epilepsycerebellumhippocampusneural circuitryoptogeneticsdeep brain stimulationseizure controlinhibitory neuronssupramammillary areabrain stimulation
Research Aims
5AIM 01Investigate the impact of cerebellar stimulation on hippocampal neuron activity during seizures.
AIM 02Study the effects of seizures on cerebellar and thalamic neuron populations.
AIM 03Examine the connectivity and function of inhibitory hippocampal projections to the supramammillary area.
AIM 04Explore the role of specific hippocampal inhibitory neuron populations in social and spatial processing.
AIM 05Identify optimal stimulation parameters for effective seizure control via cerebellar targeting.
Skills the Lab Values
optogeneticsfiber photometryimmunohistochemistryanimal behavior assayselectrophysiologydeep brain stimulation techniquesdata analysismouse modelsneuroscience experimental designcalcium imaging
Output against the department
Publications57bottom 14% of dept.579th of 671
this lab
most publishedleast published
Citations2.9kbottom 21% of dept.533rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.