University of Minnesota-Twin Cities · PharmacologyGABAB Signaling Research Lab
Kevin D Wickman · Minneapolis, Minnesota
Research Focus
Dr. Kevin D. Wickman's lab studies how certain proteins in the brain help control the signals that influence mood and behavior. They focus on understanding the mechanisms by which G protein-coupled receptors, specifically GABAB receptors, regulate brain cell signaling. By using advanced techniques, they aim to uncover new ways to treat neurological disorders that result from dysfunctional signaling pathways.
G protein-coupled receptorsGABAB signalingneurological disorderssignal transductionsynaptic plasticity
Research Aims
4AIM 01Identify mechanisms mediating GABAB receptor-effector signaling dynamics
AIM 02Investigate the organization of GABAB receptor-GIRK signalosomes
AIM 03Understand the role of R7 RGS/G5 complexes in signaling modulation
AIM 04Explore therapeutic intervention possibilities for neurological disorders
Skills the Lab Values
electrophysiologygenetic manipulationbiochemical assaysoptical imaging techniquesprotein complex analysis
Output against the department
Publications160bottom 45% of dept.254th of 462
this lab
most publishedleast published
Citations9.7ktop 39% of dept.182nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.