University of Washington-Seattle Campus · EngineeringNeuronal Activity Imaging Lab
Andre Berndt · Seattle, Washington
Research Focus
Dr. Andre Berndt's lab at the University of Washington focuses on developing advanced fluorescent sensors to monitor neuronal activity in the brain. By utilizing machine learning and high-throughput screening methods, the lab aims to create red fluorescent calcium and neuromodulator sensors that outperform existing green sensors in terms of stability and efficiency. This research is critical for advancing our understanding of brain functionality and addressing neurological disorders.
fluorescent sensorsneuronal activitymachine learningmultiplex imagingneurosciencecalcium indicatorsneuromodulatorshigh-throughput screeningin vivo validation
Research Aims
5AIM 01Develop red fluorescent calcium and neuromodulator sensors that match the performance of existing green sensors.
AIM 02Utilize machine learning to accelerate the identification of optimal sensor variants.
AIM 03Conduct comprehensive benchmarking and in vivo validation of the developed sensors.
AIM 04Enhance the dynamic range and photostability of fluorescent sensors for better performance.
AIM 05Facilitate the analysis of neuronal interactions through advanced multiplexed imaging techniques.
Skills the Lab Values
fluorescent microscopymachine learning algorithmshigh-throughput screening techniquesfiber photometrytwo-photon imagingthree-photon imagingdata analysis using Pythonsensor engineeringvalidation assaysperformance benchmarking
Output against the department
Publications413top 16% of dept.45th of 278
this lab
most publishedleast published
Citations6.9ktop 50% of dept.140th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.