University of Washington-Seattle Campus · BiochemistryKollman Lab
Justin M Kollman · Seattle, Washington
Research Focus
Dr. Justin Kollman's lab at the University of Washington focuses on the structure and function of metabolic enzyme assemblies. They study how different enzymes in cells organize and work together to maintain metabolic balance, especially under changing environmental conditions. By understanding these assemblies, the lab aims to uncover insights into diseases linked to metabolic dysfunction and the potential for new medical therapies.
metabolic enzyme assembliesenzyme dynamicscellular metabolismmetabolonsfilamentous structurespost-translational modificationmetabolic regulationnucleotide biosynthesisenergy metabolismamino acid metabolism
Research Aims
5AIM 01Investigate the structural basis of metabolic enzyme assemblies using cryo-electron microscopy.
AIM 02Explore the regulation of enzyme activity by changes in metabolic conditions.
AIM 03Determine the impact of enzyme assemblies on cellular metabolic pathways.
AIM 04Analyze the effects of post-translational modifications on enzyme dynamics.
AIM 05Examine how enzyme misregulation can lead to disease and potential therapeutic strategies.
Skills the Lab Values
cryo-electron microscopyin vitro reconstitutionbiochemical assaysbiophysical techniquescell biology techniquesspectroscopyprotein purificationmetabolic flux analysisdata analysis with Python
Output against the department
Publications173top 50% of dept.197th of 402
this lab
most publishedleast published
Citations6.8kbottom 38% of dept.251st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.