Case Western Reserve University · Genetics3D Genome Dynamics Lab
Fulai Jin · Cleveland, Ohio
Research Focus
Dr. Fulai Jin's lab focuses on understanding the three-dimensional structure of the genome and its role in gene regulation and disease, particularly how genetic variations influence DNA looping in cells. Using advanced techniques like Hi-C and deep learning, the lab investigates the intricate relationships between chromatin organization and gene expression, leveraging mouse models to draw insights relevant to human biology and diseases such as diabetes.
chromatin loopsHi-Cgenome organizationtranscription regulationepigeneticsallele-specific analysisdeep learningmouse modelsgene regulation3D genome
Research Aims
5AIM 01Map heritable chromatin loop variants in mouse pancreatic cells.
AIM 02Develop a new Hi-C pipeline to analyze chromatin loops more effectively.
AIM 03Identify the impact of genetic variants on 3D chromatin architecture.
AIM 04Integrate multiomic data to understand gene regulatory mechanisms.
AIM 05Create comparative models of 3D genome structure between mice and humans.
Skills the Lab Values
Hi-Cdeep learningallele-specific mappingchromatin interaction analysissingle cell sequencingbioinformaticsdata visualizationmouse geneticsepigenomic techniquescomputational modeling
Output against the department
Publications71bottom 17% of dept.213th of 259
this lab
most publishedleast published
Citations10ktop 49% of dept.128th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.