University of Arkansas for Medical Sciences · Biomedical EngineeringCancer Immunotherapy and Tumor Response Lab
Fen Xia · Little Rock, Arkansas
Research Focus
Dr. Fen Xia's lab focuses on improving cancer treatment, specifically for head and neck squamous cell carcinoma (HNSCC). They investigate how certain proteins affect the immune response to tumors, particularly how a pathway involving GSK3 and 53BP1 can lead to T cell exhaustion, which limits the success of immunotherapies. By understanding and disrupting this pathway, the lab aims to enhance T cell survival and effectiveness against tumors, contributing to better treatment options.
T cell exhaustionGSK353BP1immunotherapyhead and neck cancerDNA repairtumor-infiltrating lymphocytessolid tumorsradiation therapy
Research Aims
3AIM 01Investigate how GSK3 inhibits 53BP1 in T cells during DNA repair.
AIM 02Assess the effect of GSK3-53BP1 disruption on tumor-infiltrating lymphocyte function.
AIM 03Explore the therapeutic potential of using mutant 53BP1 T cells in cancer treatment.
Skills the Lab Values
cell culturemouse modelsgenetic engineeringmolecular cloningWestern blottingflow cytometryRNA sequencingimmunohistochemistrydata analysisprotein purification
Output against the department
Publications180bottom 41% of dept.346th of 595
this lab
most publishedleast published
Citations6.5kbottom 49% of dept.301st of 595
this lab
most citedleast cited
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