University of Iowa · BiologyLegge Lab
Kevin L Legge · Iowa City, Iowa
Research Focus
Dr. Kevin Legge's lab at the University of Iowa focuses on developing new vaccination strategies against Influenza A viruses, particularly those from avian sources. They are exploring the use of polyanhydride nanoparticles to create a novel vaccine that can induce strong immune responses in the lungs and nasal passages, aiming for broad protection against various strains of the virus. Their research has the potential to improve how vaccines work by promoting long-lasting immunity that is not typically achieved by current vaccines.
Avian InfluenzaNanoparticle VaccineT Cell ImmunityB Cell ImmunityVaccine DevelopmentInfluenza A VirusImmunogenicityPublic HealthRespiratory ImmunityLung Resident Memory
Research Aims
5AIM 01Develop a nanoparticle-based vaccine against avian Influenza A viruses.
AIM 02Evaluate the immune response induced by the new vaccine in animal models.
AIM 03Assess the vaccine's effectiveness in providing broad-based protection against different Influenza A strains.
AIM 04Investigate the role of lung resident memory T and B cells in long-term immunity.
AIM 05Test the efficacy of the vaccine in a pre-clinical setting.
Skills the Lab Values
Nanoparticle synthesisAnimal modelsImmunization techniquesELISA for antibody detectionFlow cytometryCell cultureWestern blotData analysis in immunologyPCRMicroscopy
Output against the department
Publications121bottom 43% of dept.584th of 1,033
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.715th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.