New York University · BiologyGenome Integrity and Diversity Unit
Andreas Hochwagen · New York, New York
Research Focus
Dr. Andreas Hochwagen's lab at New York University studies how organisms safely break their DNA to create genetic diversity. They focus on understanding programmed DNA double-strand breaks and their roles in meiotic recombination and ribosomal DNA variations. By using genetics and molecular biology techniques, the lab aims to gain insights into genome stability and its implications for human diseases.
DNA double-strand breaksmeiosisribosomal DNAgenome stabilitygenetic diversityDNA repairyeast modelevolutionary biology
Research Aims
5AIM 01Investigate the mechanisms of programmed DNA double-strand breaks in eukaryotic organisms.
AIM 02Study meiotic recombination and the factors influencing DSB formation.
AIM 03Analyze the dynamics of ribosomal DNA copy-number changes.
AIM 04Explore the evolutionary implications of genetic variation in rDNA clusters.
AIM 05Understand how DSBs contribute to genomic plasticity in health and disease.
Skills the Lab Values
molecular biology techniquesgenetic manipulationyeast geneticsgenomic analysisproteomicscell cultureCRISPRbioinformaticsmicroscopy
Output against the department
Publications87bottom 28% of dept.737th of 1,033
this lab
most publishedleast published
Citations4.8kbottom 37% of dept.654th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.