Yale University · ChemistryC-H Functionalization and Drug Discovery Lab
Jonathan A Ellman · New Haven, Connecticut
Research Focus
Dr. Jonathan A. Ellman's lab at Yale University specializes in advanced methods for modifying C-H bonds in organic molecules to create new pharmaceuticals. Their research focuses on simplifying the synthesis of complex drug-like compounds from readily available materials and applying these techniques to discover new drugs targeting urgent medical needs. The lab emphasizes innovative strategies for efficient and selective production of biologically important molecules, particularly those interacting with specific receptors in the body.
C-H functionalizationpharmaceutical chemistryorganic synthesisenzyme inhibitorsheterocyclesligand designnatural productsbiomolecular targetsmedicinal chemistry
Research Aims
5AIM 01Develop next-generation methods for C-H bond functionalization to create diverse pharmaceuticals.
AIM 02Utilize reversible light-mediated reactions to produce stable stereoisomers of complex molecules.
AIM 03Advance the synthesis of key nitrogen heterocycles relevant to drug development.
AIM 04Identify potent ligands for difficult biomolecular targets using novel synthesis techniques.
AIM 05Investigate the role of engineered compounds in modulating receptor activity related to central nervous system conditions.
Skills the Lab Values
C-H bond functionalizationsynthetic organic chemistrythree-component reactionslight-mediated reactionssynthesis of heterocyclesligand synthesisorganic synthesis techniqueschromatographyspectroscopy
Output against the department
Publications664top 11% of dept.23rd of 216
this lab
most publishedleast published
Citations40ktop 10% of dept.22nd of 216
this lab
most citedleast cited
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