University of Pennsylvania · BiologyBrodsky Immunology Lab
Igor E Brodsky · Philadelphia, Pennsylvania
Research Focus
Dr. Igor Brodsky's lab at the University of Pennsylvania focuses on how the immune system responds to infections by bacteria like Yersinia. His team studies the formation of granulomas, which are organized clusters of immune cells that help contain infections. By understanding the role of specific immune cells like inflammatory monocytes and signaling molecules such as IL-1, the lab aims to uncover mechanisms that control bacterial infections and influence public health.
innate immunityYersiniagranulomasneutrophilsinflammatory monocytesTNF-αIL-1 cytokinesinfection controlmucosal immunitybacterial infections
Research Aims
3AIM 01Define how monocyte-specific TNFR1 signaling contributes to IL-1 expression in innate immune cells.
AIM 02Dissect the role of IL-1R signaling in intestinal epithelial cells during Yersinia infection.
AIM 03Utilize next-generation sequencing and computational tools to study Yersinia replication and dissemination dynamics.
Skills the Lab Values
cell cultureflow cytometryanimal modelsPCRRNA sequencingmicroscopyWestern blotimmunohistochemistrydata analysiscomputational biology
Output against the department
Publications142top 48% of dept.495th of 1,033
this lab
most publishedleast published
Citations9.4ktop 40% of dept.417th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.