Icahn School of Medicine at Mount Sinai · PharmacologyZhou Immunology Lab
Ming-Ming Zhou · New York, New York
Research Focus
Dr. Ming-Ming Zhou's lab focuses on understanding how certain immune cells, specifically a type of T helper cell known as Th2 cells, develop and function in relation to diseases like asthma and allergies. By studying the mechanisms that control gene expression in these cells, the lab aims to uncover new targets for therapies that can better manage and potentially cure allergic diseases.
T helper cellsasthmagene transcriptionBRD4immunomodulation
Research Aims
5AIM 01Investigate the role of BRD4 in Th2 cell differentiation.
AIM 02Define molecular mechanisms of transcriptional repression by BRD4.
AIM 03Explore the potential of BRD4-BD2 inhibitors in treating Th2-mediated allergic conditions.
AIM 04Examine the interplay between transcription factors like Foxp3 and Gata3 in Th2 cells.
AIM 05Study the therapeutic implications of modulating Th2 cell development.
Skills the Lab Values
cell culturemouse modelsmolecular cloninggene expression analysisWestern blotPCRCRISPRhistone modification analysisflow cytometry
Output against the department
Publications319top 24% of dept.111th of 462
this lab
most publishedleast published
Citations26ktop 11% of dept.53rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.