University of Florida · BiochemistryXie Lab
Mingyi Xie · Gainesville, Florida
Research Focus
Dr. Mingyi Xie's lab at the University of Florida focuses on understanding how specific small RNAs called microRNAs are regulated in T-cell acute lymphoblastic leukemia (T-ALL). They are investigating a novel mechanism where mRNA can degrade microRNAs, which could lead to new strategies for treating leukemia and overcoming resistance to current therapies. The lab's work could provide insights into gene regulation and potential therapeutic approaches for cancer treatment.
T-cell acute lymphoblastic leukemiamicroRNAgene regulationcancer treatmentglucocorticoidapoptosisbiochemical protocolscomputational analysis
Research Aims
3AIM 01Investigate how BIM mRNA triggers the degradation of microRNAs miR-221/222.
AIM 02Explore the role of microRNA degradation in enhancing the killing of T-ALL cells during chemotherapy.
AIM 03Develop protocols to identify mRNAs that can induce microRNA degradation in T-ALL patient samples.
Skills the Lab Values
PCRcell cultureCRISPR technologyRNA sequencingbioinformaticsWestern blotdata analysissequencing analysisprotein expression assays
Output against the department
Publications85bottom 18% of dept.327th of 402
this lab
most publishedleast published
Citations4.1kbottom 23% of dept.311th of 402
this lab
most citedleast cited
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