UTHThe University of Texas Health Science Center at Houston · Biochemistry
Serysheva Lab
Irina I Serysheva · Houston, Texas
Research Focus
Dr. Irina Serysheva's lab focuses on understanding how calcium signaling in cells is regulated, particularly through a protein called inositol 1,4,5-trisphosphate receptor (IP3R). By studying how this receptor works at a molecular level, the lab aims to uncover its role in various diseases, including neurodegenerative disorders like Alzheimer's disease. The research combines advanced techniques in structural biology and biophysics to develop insights that could lead to new treatments for conditions caused by calcium signaling dysfunction.
calcium signalingIP3Rneurodegenerative diseasesmolecular mechanismsstructural biology
Research Aims
5AIM 01Investigate how ligands bind and affect IP3R function.
AIM 02Determine the structural basis for channel gating and regulation.
AIM 03Elucidate the molecular mechanisms of how IP3Rs contribute to calcium signaling in cells.
AIM 04Study the unique properties of different IP3R subtypes.
AIM 05Develop insights for therapeutic approaches targeting IP3R dysfunction.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)mutagenesis techniqueselectrophysiologybiochemical assaysdeep learning for structural biologyprotein purificationcell culturedata analysis with Python
Output against the department
Publications95bottom 23% of dept.310th of 402
this lab
most publishedleast published
Citations3.5kbottom 17% of dept.335th of 402
this lab
most citedleast cited
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