University of Notre Dame · ChemistryT Cell Mechanobiology Lab
Brian M Baker · Notre Dame, Indiana
Research Focus
Dr. Brian M Baker's lab at the University of Notre Dame focuses on understanding how mechanical forces influence T cell behavior in the immune system. The research involves studying the interactions between T cell receptors and peptide-MHC complexes, particularly how these interactions can change under different forces. By developing models to explain these interactions, the lab aims to manipulate T cell responses, which could lead to better strategies in immunotherapy and vaccine design.
T cell biologymechanobiologyimmune systemcatch bondssignaling dynamicsTCR-pMHC interactionsviral infection controlimmunogenicitycellular immunitymechanical forces
Research Aims
3AIM 01Develop a mechanistic framework for understanding force-dependent behavior in T cell receptors.
AIM 02Investigate how natural variations in TCR interfaces affect catch bond formation and T cell biology.
AIM 03Engineer TCR catch bonds to improve control over viral infections in animal models.
Skills the Lab Values
molecular modelingcell cultureforce spectroscopyprotein engineeringmicroscopydata analysisimmunological assaysanimal handling (mice)Western blottingPCR
Output against the department
Publications198bottom 47% of dept.113th of 216
this lab
most publishedleast published
Citations7.2kbottom 44% of dept.120th of 216
this lab
most citedleast cited
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