WMCWeill Medical College of Cornell University · Neuroscience
Luo Lab
Wenjie Luo · New York, New York
Research Focus
Dr. Wenjie Luo's lab focuses on understanding the role of microglia and cholesterol metabolism in Alzheimer's disease, particularly how a specific gene variant (APOE4) affects neuroinflammation and tau toxicity. The research aims to uncover novel cellular mechanisms and therapeutic targets by studying a cholesterol-related enzyme, CH25H, and its impact on Alzheimer’s progression. This work could lead to new prevention strategies or treatments for Alzheimer's disease.
Alzheimer's Diseasemicroglial inflammationtau toxicitycholesterol metabolismcGAS-STING signalingAPOE4CH25Htherapeutic interventionneurodegeneration
Research Aims
3AIM 01Investigate how 25-HC promotes cGAS-STING-Inflammasome signaling in microglia.
AIM 02Determine if APOE4 activates cGAS-STING-IFN pathway through CH25H.
AIM 03Assess if CH25H activity is required for APOE4-induced toxicity in tauopathy mice.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingin vivo imagingcellular signaling analysislipidomicsproteomicsantisense oligonucleotide techniquesbiological assays
Output against the department
Publications75bottom 21% of dept.528th of 671
this lab
most publishedleast published
Citations6.9kbottom 48% of dept.352nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.