UAUniversity of Arkansas · Biology
Mitochondrial Disorders Research Lab
Shilpa Iyer · Fayetteville, Arkansas
Research Focus
Dr. Shilpa Iyer's lab at the University of Arkansas focuses on understanding mitochondrial disorders, particularly in children. The lab investigates how defects in mitochondrial DNA can lead to multiple organ failures through mechanisms such as oxidative stress and metabolic dysregulation. Their research aims to develop personalized therapies by studying the cellular and metabolic responses of affected tissues in pediatric patients.
mitochondrial disordersoxidative stresspediatric diseasesmetabolic regulationpersonalized therapy
Research Aims
3AIM 01Assess the impact of mitochondrial dysfunction in pediatric dermal fibroblasts with mitochondrial DNA variants.
AIM 02Investigate tissue-specific abnormalities in neurons, cardiomyocytes, and podocytes affected by mitochondrial dysfunction.
AIM 03Evaluate targeted interventions to reduce oxidative stress and improve mitochondrial health in patient-derived cell types.
Skills the Lab Values
cell culturemetabolomicsnext-generation sequencingmitochondrial respiration assaysfibroblast differentiation
Output against the department
Publications29bottom 3% of dept.993rd of 1,033
this lab
most publishedleast published
Citations1.9kbottom 13% of dept.902nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.