The University of Texas Medical Branch at Galveston · BiologyThe Splice Defense Lab
Jere W Mcbride · Galveston, Texas
Research Focus
Dr. Jere McBride's research focuses on understanding how the intracellular bacterium Ehrlichia chaffeensis, which causes a serious tick-borne disease in humans, manipulates host cell machinery to enhance its survival and replication. The lab investigates the role of specific proteins that Ehrlichia secretes to alter RNA splicing processes in human cells, particularly those involved in immune responses. By exploring these molecular interactions, the research aims to uncover new therapeutic strategies to combat this pathogen and similar intracellular infections.
Ehrlichia chaffeensisRNA splicingHippo signalingintracellular pathogensimmune evasion
Research Aims
3AIM 01Investigate hnRNPA2B1 as a substrate of E. chaffeensis TRP120 HECT E3 Ub ligase.
AIM 02Explore the role of hnRNPA2B1 in regulating mRNA stability during infection.
AIM 03Examine pre-mRNA alternative splicing of KIRREL1 in relation to Hippo/YAP signaling.
Skills the Lab Values
cell cultureRNA sequencingWestern blotimmunoprecipitationPCR
Output against the department
Publications139top 50% of dept.510th of 1,033
this lab
most publishedleast published
Citations6.0kbottom 43% of dept.585th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.