University of Pennsylvania · BiologyTDP-43 and Neurodegeneration Lab
Silvia Porta Antolinez · Philadelphia, Pennsylvania
Research Focus
Dr. Silvia Porta Antolinez's lab at the University of Pennsylvania studies the role of a protein called TDP-43 in brain diseases, particularly in age-related dementias like frontotemporal lobar degeneration (FTLD) and Alzheimer's disease. They focus on understanding the differences and behaviors of TDP-43 across various brain conditions and how these differences might help in developing better diagnostic and therapeutic strategies for dementia.
TDP-43frontotemporal degenerationAlzheimer's diseaseneuropathologyprotein aggregation
Research Aims
3AIM 01Isolate and characterize TDP-43 species from FTLD-TDP and LATE-NC brains.
AIM 02Generate in vitro models to study brain-derived TDP-43 strains.
AIM 03Analyze pathophysiological signaling pathways associated with different TDP-43 proteinopathies.
Skills the Lab Values
immunohistochemistrybrain tissue analysismolecular biology techniquesgenetic sequencingbioinformatics analysis
Output against the department
Publications1bottom 1% of dept.1,030th of 1,033
this lab
most publishedleast published
Citations0bottom 1% of dept.1,028th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.