PSUPortland State University · Chemistry
Kancharla Antimalarial Lab
Papireddy Kancharla · Portland, Oregon
Research Focus
Dr. Kancharla's lab at Portland State University focuses on creating new and improved treatments for malaria, a disease that affects millions around the world. They are particularly interested in developing novel drugs based on natural products that can effectively attack the malaria parasite at different stages of its life cycle. By finding new drug candidates that can overcome issues like drug resistance, the lab aims to significantly contribute to public health and the fight against malaria.
malariaantimalarialsnatural productsdrug resistancemedicinal chemistryprodigininetambjaminepublic healthpharmaceutical development
Research Aims
5AIM 01Develop novel antimalarial drugs using natural product-inspired chemotypes.
AIM 02Investigate and optimize drug candidates for efficacy against multiple stages of the malaria parasite.
AIM 03Conduct studies to understand the mechanisms of action of the new antimalarial drugs.
AIM 04Assess the potential for drug resistance in selected candidates through genomic analysis.
AIM 05Advance lead compounds to further preclinical development for potential clinical trials.
Skills the Lab Values
chemical synthesisin vitro drug testinganimal modelswhole genome sequencingpharmacokinetics studiesmetabolic stability analysisoral bioavailability assessmentbiological assaysdata analysis using statistical software
Output against the department
Publications31bottom 6% of dept.203rd of 216
this lab
most publishedleast published
Citations777bottom 6% of dept.204th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.