University of California-San Diego · ChemistryThe Immunogen Initiative
Partho Ghosh · La Jolla, California
Research Focus
Dr. Partho Ghosh's lab at UC San Diego focuses on developing vaccines against Streptococcus pyogenes, a dangerous bacterium that causes significant health issues worldwide. The research aims to find ways to create immunogens that generate responses to multiple strains of this pathogen by studying the structural characteristics of its M proteins. This work could lead to more effective vaccines and improve our understanding of immune responses to this bacterium.
Streptococcus pyogenesM proteinsimmune responsevaccine developmentcross-reactive antibodies
Research Aims
4AIM 01Develop an M protein-based immunogen with broad cross-reactivity.
AIM 02Investigate antibody interactions with M proteins using crystallography.
AIM 03Identify structural features of cross-reactive human antibodies.
AIM 04Enhance protection across different Streptococcus pyogenes strains.
Skills the Lab Values
X-ray crystallographysite-directed mutagenesisprotein purificationantibody characterizationstructural biology techniques
Output against the department
Publications214top 49% of dept.106th of 216
this lab
most publishedleast published
Citations7.8kbottom 46% of dept.116th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.