University of Florida · PhysiologyChronic Limb Ischemia Research Lab
Terence E Ryan · Gainesville, Florida
Research Focus
Dr. Terence E. Ryan's lab at the University of Florida focuses on understanding a serious condition called chronic limb threatening ischemia (CLTI), which is a critical form of peripheral artery disease. They investigate how fatty fibrosis, an abnormal replacement of muscle with fat and scar tissue, affects blood flow and muscle function in CLTI patients. By studying molecular signaling pathways, particularly the ciliary Hedgehog signaling, the lab aims to identify potential therapeutic targets to improve outcomes for patients suffering from this debilitating condition.
Chronic limb threatening ischemiafatty fibrosisHedgehog signalingangiogenesisperipheral artery disease
Research Aims
4AIM 01Investigate the role of fatty fibrosis in the muscle of CLTI patients.
AIM 02Explore ciliary Hedgehog signaling in regulating intramuscular fat.
AIM 03Examine the effects of therapeutic alterations in Hedgehog signaling on limb function.
AIM 04Identify cellular mechanisms underlying fatty fibrosis formation in CLTI limbs.
Skills the Lab Values
mouse modelsmolecular biology techniqueshistologyRNA analysisangiogenesis assays
Output against the department
Publications210top 31% of dept.87th of 286
this lab
most publishedleast published
Citations9.4ktop 36% of dept.104th of 286
this lab
most citedleast cited
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