Thomas Jefferson University · BiologyLab of RNA Modifications and Cognitive Development
Niraj Lodhi · Philadelphia, Pennsylvania
Research Focus
Dr. Niraj Lodhi's lab at Thomas Jefferson University focuses on how early life lead exposure affects brain development and memory through changes in RNA methylation. The research explores the role of a specific RNA modification, m6A, in cognitive functions, particularly its influence on memory-related genes. By investigating these mechanisms, the lab aims to understand the long-term consequences of lead exposure on learning and behavior.
m6A RNA methylationlead exposureneural plasticitymemory disorderscognitive deficits
Research Aims
3AIM 01Examine the effect of developmental lead exposure on m6A RNA methylation in key brain regions and its association with memory deficits.
AIM 02Investigate the functional role of m6A RNA modification in memory processes affected by lead exposure.
AIM 03Determine if manipulating m6A methylation can ameliorate cognitive impairments caused by lead exposure.
Skills the Lab Values
m6A-eCLIPRNA extractionWestern blotimmunoprecipitationanimal modelsbehavioral assaysviral transductiongene expression analysisPCR
Output against the department
Publications48bottom 11% of dept.916th of 1,033
this lab
most publishedleast published
Citations913bottom 4% of dept.992nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.