Harvard University · ChemistryThe Adaptive Resistance Laboratory
Eugene I Shakhnovich · Cambridge, Massachusetts
Research Focus
Dr. Eugene I Shakhnovich's lab at Harvard University focuses on understanding how bacteria adapt to challenges like antibiotic stress through rigorous experimental and theoretical approaches. By developing models that map the relationship between molecular properties and evolutionary fitness, the lab aims to predict how pathogens evolve and resist treatment. This research could lead to innovative strategies for combating antibiotic resistance and improving therapeutic interventions.
Antibiotic ResistanceBiophysical Fitness LandscapeE. coliProtein EngineeringGenotype-Phenotype RelationshipMultiscale ModelingDrug ResistanceMolecular MappingCodon Adaptation
Research Aims
5AIM 01Develop predictive multiscale biophysical models of evolutionary dynamics.
AIM 02Explore the relationship between molecular properties and bacterial fitness.
AIM 03Characterize evolutionary pathways of E. coli under antibiotic stress.
AIM 04Identify biophysical principles governing codon adaptation and protein folding.
AIM 05Design new compounds to combat pathogen resistance.
Skills the Lab Values
PCRProtein EngineeringGenomic EditingMolecular CloningMetabolomicsProteomicsExperimental DesignRobotics AutomationData Modeling
Output against the department
Publications473top 18% of dept.39th of 216
this lab
most publishedleast published
Citations21ktop 23% of dept.50th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.