UMCUniversity of Massachusetts Chan Medical School · Biochemistry
Cell Growth and Division Laboratory
Nicholas R Rhind · Worcester, Massachusetts
Research Focus
The Rhind lab at the University of Massachusetts Medical School focuses on understanding how cells control their growth and division, particularly in the context of size homeostasis and DNA replication. They explore questions such as how cells decide when to divide and how they manage the timing of DNA replication, which are critical for maintaining genome stability and preventing diseases like cancer. Using model organisms like fission yeast, the lab aims to unravel the mechanisms behind these essential cellular processes, which have implications for understanding human health and disease.
cell cycleDNA replicationcell size regulationfission yeastgenome stabilitycancer biologymitosiscell homeostasischromatin modification
Research Aims
5AIM 01Investigate how fission yeast regulates cell size during division.
AIM 02Explore the timing of DNA replication origin firing.
AIM 03Understand the relationship between cell size and mitotic activators.
AIM 04Analyze the correlation between DNA replication timing and gene expression.
AIM 05Develop techniques to measure origin firing probability across the genome.
Skills the Lab Values
PCRcell culturesingle-molecule origin mappinggenetic engineeringWestern blotmicroscopydata analysisyeast geneticsprotein purification
Output against the department
Publications191top 45% of dept.178th of 402
this lab
most publishedleast published
Citations29ktop 12% of dept.49th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.