UTHThe University of Texas Health Science Center at Houston · Neuroscience
Manwani Lab
Bharti Manwani · Houston, Texas
Research Focus
Dr. Bharti Manwani's lab at the University of Texas Health Science Center focuses on understanding how atrial fibrillation, a heart condition, disproportionately affects elderly women and leads to dementia. Through innovative animal models, the lab investigates the influence of sex chromosomes and hormones on disease development and seeks to identify potential therapeutic targets for prevention. The research integrates advanced techniques in electrophysiology, imaging, and molecular biology to unravel complex sex-specific mechanisms involved in these conditions.
atrial fibrillationdementiasex differencesinflammationfibrosiscardiac healthanimal modelssex hormonesMRIflow cytometry
Research Aims
5AIM 01Investigate the link between atrial fibrillation and dementia, particularly in elderly women.
AIM 02Study sex differences in inflammation and fibrosis related to atrial fibrillation.
AIM 03Identify gene-directed inflammatory pathways that could serve as therapeutic targets.
AIM 04Assess the role of pharmacological inhibitors on atrial fibrillation and dementia risk.
AIM 05Understand the impact of sex chromosomal complement on heart-brain interactions.
Skills the Lab Values
mouse modelselectrophysiologyMRI imagingflow cytometryimmunohistochemistrybehavioral testinggene manipulationELISAoptical mappingdata analysis
Output against the department
Publications52bottom 11% of dept.591st of 671
this lab
most publishedleast published
Citations1.3kbottom 7% of dept.621st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.