Yale University · BiologyCell Size and Immune Function Lab
Min Wu · New Haven, Connecticut
Research Focus
Dr. Min Wu's lab at Yale University explores how cell size impacts immune function and aging. They are particularly interested in how larger immune cells can still operate effectively without becoming senescent, which is a state of irreversible growth arrest often linked to aging. By studying pathways that regulate cell size, the lab aims to uncover new strategies to combat age-related immune dysfunction.
cell size inheritanceimmune memoryagingcell senescenceFBP17macrophagesmonocytesimmune exhaustioncell growth mechanismstransgenerational memory
Research Aims
5AIM 01Investigate how cell size increment is regulated in immune cells.
AIM 02Examine the role of FBP17 in cell size and immune function.
AIM 03Explore the relationship between immune exhaustion and cell size.
AIM 04Study the transgenerational memory mechanism in cell growth.
AIM 05Identify new strategies for reversing age-related cell size effects.
Skills the Lab Values
cell culturesingle-cell analysismolecular cloningflow cytometrygene knockdown techniquesmonitoring cell growthcellular morphology analysisbiochemical assayslineage tracingin vitro stimulation assays
Output against the department
Publications1,135top 1% of dept.9th of 1,033
this lab
most publishedleast published
Citations30ktop 11% of dept.117th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.