University of Pennsylvania · Biomedical EngineeringThe NeuroPathology Lab
Paul A. Yushkevich · Philadelphia, Pennsylvania
Research Focus
Dr. Paul A. Yushkevich's lab focuses on understanding Alzheimer's disease (AD) by examining the brain's structure and pathology postmortem. The lab utilizes advanced imaging techniques to analyze how various pathological features, such as tau tangles and amyloid plaques, correlate with neuronal loss and cognitive decline. This research aims to improve the effectiveness of clinical trials for AD treatments by uncovering the complex relationships between different brain pathologies and their impact on neurodegeneration.
Alzheimer's Diseaseneurodegenerationbrain imagingpathologyMRIdeep learningcognitive impairmentbiomarkersco-pathologies
Research Aims
3AIM 01Develop deep learning techniques for analyzing high-resolution MRI of human brain specimens.
AIM 02Characterize the distribution of tau pathology and neuronal loss across different brain regions.
AIM 03Improve in vivo biomarkers for tracking Alzheimer's disease progression based on ex vivo findings.
Skills the Lab Values
MRI imaginghistological analysisdeep learning for image processingneuron quantificationdata analysis with Pythonpathological feature extraction3D mapping techniquesneuroanatomyclinical trial design
Output against the department
Publications513top 15% of dept.92nd of 595
this lab
most publishedleast published
Citations30ktop 9% of dept.55th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.