University of Arizona · Microbiology & ImmunologyPlasma Cell Immunity Lab
Deepta Bhattacharya · Tucson, Arizona
Research Focus
Dr. Deepta Bhattacharya's research lab focuses on understanding the molecular mechanisms behind antibody responses and immunity. They investigate how specific metabolic pathways influence the lifespan and function of plasma cells, which are crucial for long-term immune protection. By using advanced genetic tools and various experimental models, the lab aims to uncover the cellular and metabolic factors that determine how long antibodies remain effective after vaccination or infection.
plasma cellsantibody responsesimmunitymetabolismtranscriptional regulationB cellsCRISPRlong-lived plasma cellshumoral immunitycellular metabolism
Research Aims
5AIM 01Define molecular programs that lead to long-lived plasma cells.
AIM 02Investigate transcriptional and epigenetic features of memory B cells.
AIM 03Explore how metabolism supports plasma cell survival and antibody secretion.
AIM 04Characterize mitochondrial dynamics in plasma cell energy metabolism.
AIM 05Identify genetic factors that influence antibody-mediated immunity.
Skills the Lab Values
CRISPR/Cas9single-cell RNA sequencingmetabolomicscell culturemouse modelsflow cytometrygenetic manipulationimaging mass spectrometryvivo studies
Output against the department
Publications155top 42% of dept.204th of 486
this lab
most publishedleast published
Citations9.2ktop 39% of dept.190th of 486
this lab
most citedleast cited
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