University of Michigan-Ann Arbor · BiologyChronic Lung Disease Immunology Lab
Nicholas W Lukacs · Ann Arbor, Michigan
Research Focus
Dr. Nicholas Lukacs's lab at the University of Michigan focuses on understanding how the immune system reacts to viruses and allergens in chronic lung diseases like severe asthma. The research aims to uncover the mechanisms behind changes in lung function and structure, which can lead to better therapies. The lab studies the roles of different immune cells and molecules, particularly during early disease stages, and how they might influence long-term health outcomes.
asthmachronic lung diseaseviral infectionsallergen exposureimmune responsecytokinesepigeneticscell metabolismlung developmentsteroid resistance
Research Aims
3AIM 01Investigate how early RSV infection affects lung immune cell development and structure.
AIM 02Explore the role of stem cell factor in activating immune cells in chronic lung disease.
AIM 03Examine how cell metabolism influences the severity of immune reactions during chronic disease.
Skills the Lab Values
cell cultureflow cytometryPCRmouse modelsWestern blotRNA sequencingimmunohistochemistrymetabolic assaysepigenetic analysismulticolor flow cytometry
Output against the department
Publications544top 6% of dept.67th of 1,033
this lab
most publishedleast published
Citations42ktop 7% of dept.69th of 1,033
this lab
most citedleast cited
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